New Oxygenated Lignans from Kadsura philippinensis |
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| Authors: | Ya‐Ching Shen Yu‐Chi Lin Yuan‐Bin Cheng Chia‐Ju Chang Ting‐Wei Lan Shorong‐Shii Liou Ching‐Te Chien Chia‐Ching Liaw Ashraf Taha Khalil |
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| Affiliation: | 1. School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan 100, Republic of China, (phone: +886‐02‐3123456, ext. 2226;2. fax: +886‐02‐23919098);3. Department of Marine Biotechnology and Resources, National Sun Yat‐Sen University, Kaohsiung 804, Taiwan, Republic of China;4. Department of Pharmacy, Tajen University, Yen‐Pou, Ping Tung Shien, Taiwan, Republic of China;5. Division of Silviculture, Taiwan Forestry Research Institute, Taipei, Taiwan, Republic of China |
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| Abstract: | ![]()
Seven new oxygenated lignans, kadsuphilins G–M ( 1 – 7 , resp.), were isolated by chromatographic fractionation of an AcOEt extract of the aerial part of Kadsura philippinensis including four compounds with a dibenzocyclooctadiene skeleton, two with a bicyclooctane ring system, and one of 1,4‐biphenyldimethylbutane type. The structures of the isolated compounds were elucidated through extensive spectroscopic analyses, particularly 2D‐NMR experiments (HMQC, HMBC, and NOESY). The configuration of the chiral centers and the biphenyl moiety were determined by NOESY as well as CD spectroscopy, respectively. |
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| Keywords: | Kadsura philippinensis Kadsuphilins G – M Lignans Dibenzocyclooctadienes |
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