| 纳米二氧化钛对卵巢肿瘤细胞的选择性凋亡的诱导作用 |
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| 引用本文： | 朱融融,汪世龙,陈小平,孙晓宇,张蕤,姚思德. 纳米二氧化钛对卵巢肿瘤细胞的选择性凋亡的诱导作用[J]. 化学学报, 2006, 64(21): 2161-2164 |
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| 作者姓名： | 朱融融 汪世龙 陈小平 孙晓宇 张蕤 姚思德 |
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| 作者单位： | 同济大学生命科学与技术学院,上海,200092;同济大学生命科学与技术学院,上海,200092;同济大学生命科学与技术学院,上海,200092;同济大学生命科学与技术学院,上海,200092;同济大学生命科学与技术学院,上海,200092;同济大学生命科学与技术学院,上海,200092 |
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| 基金项目： | 国家自然科学基金(No.50572074)，上海市纳米专项(No.0552nm028)资助项目. |
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| 摘 要： | 以人肾上皮细胞293T和中国仓鼠卵巢肿瘤细胞CHO为研究对象, 通过MTT法酶标仪检测、倒置显微镜观察和DNA ladder实验等方法, 研究了锐钛型TiO2对它们的选择性凋亡诱导作用. 实验结果表明, 纳米TiO2对肿瘤细胞具有非常明显的毒性作用, 可侵入细胞内部, 诱导CHO细胞产生细胞凋亡. 对于293T细胞, 虽然会抑制其增殖, 但不能够进入细胞膜内, 没有细胞凋亡现象的发生. 这一结论为利用纳米TiO2治疗癌症提出了一条新思路.
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| 关 键 词： | 纳米TiO2 CHO细胞 293T细胞 细胞凋亡 细胞毒性 |
| 收稿时间： | 2006-04-26 |
| 修稿时间： | 2006-04-26 |
Selective Apoptosis Inducing Effect of Nano-TiO2 on CHO Cells |
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| ZHU,Rong-Rong,WANG,Shi-Long,CHEN,Xiao-Ping,SUN,Xiao-Yu,ZHANG,Rui,YAO,Si-De. Selective Apoptosis Inducing Effect of Nano-TiO2 on CHO Cells[J]. Acta Chimica Sinica, 2006, 64(21): 2161-2164 |
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| Authors: | ZHU Rong-Rong WANG Shi-Long CHEN Xiao-Ping SUN Xiao-Yu ZHANG Rui YAO Si-De |
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| Affiliation: | (School of Life Science and Technology, Tongji University, Shanghai 200092) |
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| Abstract: | The diluted nano-TiO2 was used to treat 293T cells and CHO cells. 293T represents human kid- ney epithelium which belongs to normal cells, while CHO represents Chinese hamster ovary tumor cells. With the method of MTT assay, inverted microscope and DNA ladder experiment, the cytotoxic and apop- tosis effects of nano-TiO2 on the two types of cells were studied. The results indicated that nano-TiO2 had much more severe toxic effect on CHO cells. After treatment, nano-TiO2 entered into the CHO cells and also induced cell apoptosis. These reactions did not take place in the case of 293T, although nano-TiO2 sup- pressed the multiplication of 293T. This finding might be significant for cancer therapy. |
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| Keywords: | nano-TiO2 CHO cell 293T cell apoptosis cytotoxicity |
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