| Influences of the Hydrophobicity of the Heme-binding Pocket on the Properties and Functions of Cytochrome b_5 Mutants |
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| 作者姓名： | 甘建华 王韵华 邬键 黄仲贤 夏宗芗 |
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| 作者单位： | State Key Laboratory of Bioorganic and Natural Products Chemistry，Chemical Biology Laboratory，State Key Laboratory of Bioorganic and Natural Products Chemistry，Chemical Biology Laboratory，State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China，Department of Chemistry，Fudan University，Shanghai 200433，China，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China，Department of Chemistryand Biochemistry，University of California at SanDiego，San Diego，CA92093，USA，Department of Chemistry，Fudan University，Shanghai 200433，China，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (Nos .3 9970 15 9,2 973 10 3 0,3 9990 60 0 ) |
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| 摘 要： | IntroductionElectrontransferreactionsarethekeystepsinphoto synthesis ,respirationandmanyotherbiochemicalprocess es.1Cytochromeb5isaredoxproteinexistingwidelyinnature ,whichactsasanelectron carrierduringvariouselectrontransferprocessesinthebiologicalsystem .2Cytochromeb5isamembraneproteinwithmolecularweightofapproximately 16kDa ,ofwhichthehydrophobicC terminaldomainanchorscytochromeb5tothemem brane ,andthehydrophilicN terminaldomaincontainshemeprostheticgroupandexhibitsthebiologicalfunctionsof…
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Influences of the Hydrophobicity of the Heme-binding Pocket on the Properties and Functions of Cytochrome b_5 Mutants |
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| GAN,Jian Hua a WANG,Yun Hua b WU,Jian #,a HUANG,Zhong Xian,b XIA,Zong Xiang,a a State Key Laboratory of Bioorganic and Natural Products Chemistry.Influences of the Hydrophobicity of the Heme-binding Pocket on the Properties and Functions of Cytochrome b_5 Mutants[J].Chinese Journal of Chemistry,2003(10). |
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| Authors: | GAN Jian Hua a WANG Yun Hua b WU Jian # a HUANG Zhong Xian b XIA Zong Xiang a a State Key Laboratory of Bioorganic and Natural Products Chemistry |
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| Institution: | GAN,Jian Hua a WANG,Yun Hua b WU,Jian #,a HUANG,Zhong Xian,b XIA,Zong Xiang,a a State Key Laboratory of Bioorganic and Natural Products Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China b Chemical Biology Laboratory,Department of Chemistry,Fudan University,Shanghai 200433,China |
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| Abstract: | |
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| Keywords: | cytochrome b 5 mutant heme binding pocket solvent accessible area hydrophobicity structure function relationship |
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