Stereoselective synthesis of 2-alkylidene-3,4-dihydro-3-oxo-2h-1,4-benzothiazines |
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| Authors: | F Babudri L Di Nunno S Florio |
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| Institution: | Istituto di Chimica Organica, Universitá di Bari, Via Amendola, 173, 70126 Bari, Italy |
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| Abstract: | Metallation of 4-methyl-3,4-dihydro-3-oxo--2H-1,4-benzothiazine with LDA and subsequent reaction with aldehydes leads to diastereomeric aldols 4 and 5. Acetylation followed by acetic acid elimination of the aldols provides a stereoselective and high yield route to 2-alkylidene-3,4-dihydro-3-oxo-2H-1,4-benzothiazines. |
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