| 2-取代-4(5)-烷氧基咪唑的合成 |
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| 引用本文： | 施耀曾,蒋卫平,陆婉芳,王丰玲,胡宏纹.2-取代-4(5)-烷氧基咪唑的合成[J].有机化学,1989,9(5):467-470. |
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| 作者姓名： | 施耀曾 蒋卫平 陆婉芳 王丰玲 胡宏纹 |
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| 作者单位： | 南京大学化学系 南京 |
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| 基金项目： | 国家自然科学基金资助课题。 |
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| 摘 要： | 我们曾报道了N-氰甲基苯甲亚氨酸乙酯(1a)的烷基化反应、Micheal加成和与芳醛的缩合反应。本文报道碱催化下N-氰甲基亚氨酸乙酯在醇中的成环反应结果。在固-液相转移催化条件下,N-氰甲基苯甲亚氨酸乙酯(1 a)与丙烯酸甲酯反应,生成Micheal加成产物。当用乙醇钠作碱、乙醇作溶剂时,1a与丙烯酸甲酯反应没有生成Micheal
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| 关 键 词： | 亚氨酸酯 咪唑 合成 成环 |
Synthesis of 2-Substituted-4(5)-Alkoxyimidazoles |
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| SHI Yao-Zeng,JIANG Wei-Ping,LU Wan-Fang,WANG Feng-Ling.Synthesis of 2-Substituted-4(5)-Alkoxyimidazoles[J].Chinese Journal of Organic Chemistry,1989,9(5):467-470. |
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| Authors: | SHI Yao-Zeng JIANG Wei-Ping LU Wan-Fang WANG Feng-Ling |
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| Institution: | SHI Yao-Zeng,JIANG Wei-Ping,LU Wan-Fang,WANG Feng-Ling,Department of chemistry,Nanjing University,Nanjing |
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| Abstract: | Ethyl N-cyanomethylimidates reacted with alcohol to give 2-substituted-4(5)- alkoxyimidazoles in the presence of sodium alkoxide or potassium carbonate. The yield varies from 52 to 87%. This is an efficient synthetic method for 2-substituted-4(5)-alkoxyi- midazoles. Eight ethyl N-cyanomethylimidates and fifteen imidazole derivatives were synthe- sized. The reaction mechanism was also suggested. |
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| Keywords: | imidate imidazole synthesis cyclization |
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