| 应用镧探针对不同心功能心脏病人活检心肌通透性观察 |
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| 引用本文： | 陈念祖,邵英杰,刘治全,马爱群,杨鼎颐,刘琼,于冬雁.应用镧探针对不同心功能心脏病人活检心肌通透性观察[J].宁波大学学报(理工版),2000,13(3):4-12. |
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| 作者姓名： | 陈念祖 邵英杰 刘治全 马爱群 杨鼎颐 刘琼 于冬雁 |
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| 作者单位： | 1. 宁波大学医学院，浙江 宁波 315211
2. 西安医科大学附属第一医院，陕西西安710061 |
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| 摘 要： | 在心力衰竭发生和演变过程中，心肌细胞膜的损伤程度起重要的作用，以往的研究证实镧 离子可作为心肌通透性的示踪元素，本文应用镧探针对四种不同心功能心脏病人及健康人活检心肌的通透性进行对比性研究，发现镧颗粒以不同程度渗透进入心肌细胞膜，肌原纤维及接的肌膜的线粒体，它们的通透程度与心功能状态一致，提示这些改变对了解心力的机制十分重要。
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| 关 键 词： | 心肌细胞膜 镧探针 心脏病 活检 心肌通透性 |
| 文章编号： | 1001-5132(2000)03-0004-09 |
The Permeability of Myocardial Biopsy Specimen from Heart Patients within Different Function State Observed by Lanthanum Probe |
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| CHEN Nian-zu,SHAO Ying-jie,LIU Zhi-quan,MA Ai-qun,YANG Ding-yi,LIU Qiong,YU Dong-yan.The Permeability of Myocardial Biopsy Specimen from Heart Patients within Different Function State Observed by Lanthanum Probe[J].Journal of Ningbo University(Natural Science and Engineering Edition),2000,13(3):4-12. |
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| Authors: | CHEN Nian-zu SHAO Ying-jie LIU Zhi-quan MA Ai-qun YANG Ding-yi LIU Qiong YU Dong-yan |
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| Abstract: | Alteration of cardiac cell membrane integrity may play an impotent role in the development and evolution of heart failure. In present primary study, used lanthanum nitrate as a tracer, the permeability of myocardial cells in specimens from biopsies in four kinds of heart patients within different function state and a healthy control were observed. The results showed that in heart patients, lanthanum particles penetrated the cardiac cell membrane in varying degrees and distributed within myofibril, mitochondria near subsarcolemma. The degrees of cardiac cell membrane and mitochondria penetrated by lanthanum salt were correlated with heart function state. It was suggested that the changes were significant in learning mechanisms of myocardial cell failure. |
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| Keywords: | lanthanum tracer cardiac cell membrane mitochondria permeability heart failure |
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