Synthesis of 1,2-Diamino-1-phenylpropane Diastereoisomers from <Emphasis Type="Italic">u</Emphasis>-<Emphasis Type="Italic">N</Emphasis>-Trifluoroacetyl-2-amino-1-phenylpropan-1-ol |
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| Authors: | Email author" target="_blank">Fran?ois?DufrasneEmail author Jean?Nève |
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| Institution: | (1) Laboratory of Organic Pharmaceutical Chemistry, Institut de Pharmacie, Université Libre de Bruxelles, Campus Plaine, CP205/5, 1050 Brussels, Belgium |
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| Abstract: | Summary. A new simple procedure for the synthesis of diastereomeric 1,2-diamino-1-phenylpropanes starting from u-N-trifluoroacetyl-2-amino-1-phenylpropan-1-ol (N-trifluoroacetylnorephedrine) is described. The trifluoroacetyl protecting group was particularly suitable for the protection of the amino group in order to reduce side reactions. |
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| Keywords: | , Amino alcohols, Configuration, Diastereoselectivity, Diamines, Protecting groups, |
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