Organocatalytic asymmetric alpha-bromination of aldehydes and ketones |
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| Authors: | Bertelsen Søren Halland Nis Bachmann Stephan Marigo Mauro Braunton Alan Jørgensen Karl Anker |
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| Affiliation: | Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University. |
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| Abstract: | The first organocatalytic enantioselective alpha-bromination of aldehydes and ketones is presented; a C2-symmetric diphenylpyrrolidine catalyst afforded the alpha-brominated aldehydes in good yields and up to 96% ee, while ketones were alpha-brominated by a C2-symmetric imidazolidine in up to 94% ee; furthermore, the organocatalytic enantioselective alpha-iodination of aldehydes is also demonstrated to proceed with up to 89% ee. |
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