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Intranasal delivery of transforming growth factor-beta1 in mice after stroke reduces infarct volume and increases neurogenesis in the subventricular zone |
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| Authors: | Minmin Ma Yuping Ma Xueming Yi Ruibing Guo Wusheng Zhu Xinying Fan Gelin Xu ll" target="_blank">William H Freyll Xinfeng Liu |
| Institution: | (1) Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305# East Zhongshan Road, Nanjing, Jiangsu Province, PR, 21002, China;(2) Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USA;(3) Alzheimer's Research Center, Regions Hospital, 640 Jackson Street, St. Paul, MN 55101, USA |
| Abstract: | BackgroundThe effect of neurotrophic factors in enhancing stroke-induced neurogenesis in the adult subventricular zone (SVZ) is limited by their poor blood-brain barrier (BBB) permeability. |
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