Effects of hypoglycemia on human brain activation measured with fMRI |
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Authors: | Anderson Adam W Heptulla Rubina A Driesen Naomi Flanagan Daniel Goldberg Philip A Jones Timothy W Rife Fran Sarofin Hedy Tamborlane William Sherwin Robert Gore John C |
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Institution: | Department of Biomedical Engineering, School of Engineering, Vanderbilt University, Nashville, TN 37232-2675, USA. adam.anderson@vanderbilt.edu |
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Abstract: | Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory stimulation on brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast, which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50 +/- 1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects: the fractional signal change was reduced by 28 +/- 12% (P < .05). These changes were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain. |
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