Solvent-free synthesis of dihydropyrimidinones catalyzed by alumina sulfuric acid at room temperature |
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| Authors: | S Besoluk M Kucukislamoglu M Nebioglu M Zengin M Arslan |
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| Institution: | 1. Faculty of Education, Department of Science Education, Sakarya University, 54300, Sakarya, Turkey
2. Faculty of Arts and Sciences, Department of Chemistry, Sakarya University, 54100, Sakarya, Turkey
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| Abstract: | A simple, efficient and practical procedure for the Biginelli reaction using alumina sulfuric acid (ASA) as a novel acid catalyst is described under solvent-free conditions. The catalyst exhibited remarkable reactivity at room temperature. The method offers several advantages including high yields, environmentally friendly procedure, short reaction times and simple work up procedure. |
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