Imines that react with phenols in water over a wide pH range |
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Authors: | Minakawa Maki Guo Hai-Ming Tanaka Fujie |
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Affiliation: | Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. |
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Abstract: | ![]() Cyclic imine derivatives that react with phenols, including tyrosine residues of peptides, have been developed. Reactions of the imines with phenols proceeded in water over a wide pH range (pH 2-10) at room temperature to 37 degrees C and afforded Mannich products without the need of additional catalysts. |
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