Differentiation of bone metastases from prostate cancer and benign red marrow depositions of the pelvic bone with multiparametric MRI |
| |
| Institution: | 1. Center for Life NanoScience@LaSapienza, Istituto Italiano di Tecnologia, Rome, Italy;2. CNR ISC UOS Roma Sapienza, Physics Department, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy;3. Enrico Fermi Center, Rome, Italy;4. Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging an Radiotherapy, PTV Foundation “Tor Vergata” University of Rome, Rome, Italy;5. Center for the prevention, diagnosis and treatment of osteoporosis, Rehabilitation Hospital IRCCS Santa Lucia Foundation, Rome, Italy;6. Department of Orthopaedics and Traumatology, PTV Foundation, “Tor Vergata” University of Rome, Rome, Italy;7. Anatomic Pathology Section, Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Rome, Italy;8. “Multidisciplinary Study of the Effects of Microgravity on Bone Cells” Project, Italian Space Agency (ASI), Spatial Biomedicine Center, Via del Politecnico snc, Rome, Italy;9. Department of Radiology, Biomedical Magnetic Resonance University Hospital Tübingen and High Field Magnetic Resonance, Max-Planck Institute for Biological Cybernetics Tübingen, Tübingen, Germany;10. Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy |
| |
| Abstract: | PurposeTo investigate the diagnostic utilities of imaging parameters derived from T1-weighted imaging (T1WI), diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to differentiate bone metastases from prostate cancer and benign red marrow depositions of the pelvic bone.Materials and methodsThirty-six lesions from 36 patients with prostate cancer were analyzed with T1WI, DWI, and DCE-MRI. The lesions were classified in the bone metastases (n = 22) and benign red marrow depositions (n = 14). Lesion-muscle ratio (LMR), apparent diffusion coefficient (ADC), volume transfer constant (Ktrans), reflux rate (Kep), and volume fraction of the extravascular extracellular matrix (Ve) values were obtained from the lesions. The imaging parameters of the both groups were compared using the Mann-Whitney U test, receiver operating characteristics (ROC) curves were analyzed. For the ROC curves, area under the curves (AUCs) were compared.ResultsThe ADC, Ktrans, Kep, and Ve values of bone metastases were significantly higher than those of benign red marrow depositions (Mann-Whitney U test, p < 0.05). However, there was no significant difference in LMR between the two groups (Mann-Whitney U test, p = 0.360). The AUCs of Ktrans, Kep, ADC, Ve, and LMR were 0.896, 0.844, 0.812, 0.724, and 0.448, respectively. In the pairwise comparison of ROC curves, the AUCs of Ktrans and Kep was significantly higher than LMR.ConclusionsKtrans, Kep, Ve, and ADC values can be used as imaging tools to differentiate bone metastases from prostate cancer and benign red marrow depositions of the pelvic bone. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
