Determination of the acyl moieties of the antibiotic complex A40926 and their relation with the membrane lipids of the producer strain. |
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Authors: | L F Zerilli D M Edwards A Borghi G G Gallo E Selva M Denaro G C Lancini |
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Institution: | Marion Merrell Dow Research Institute, Lepetit Research Center, Grenezano, Varese, Italy. |
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Abstract: | Structures of the fatty acid residues characterizing the various components of A40926 were determined by gas chromatography/mass spectrometry on the methyl esters obtained by methanolysis of the complex. The results confirm the residues previously assigned to Factor A (n-undecanoic acid) and B (10-methyl-undecanoic acid) and establish the residues of Factor A1 (9-methyl-decanoic acid), B1 (n-dodecanoic acid), RS1 (8-methyl-nonanoic acid), RS2 (n-decanoic acid), and RS3 (n-tridecanoic acid). As the Actinomadura species contain in their mycelia large quantities of C15-C17 fatty acid residues as membrane phospholipids, these mycelia were saponified and the fatty acids obtained were analyzed as above. There is a close correlation between the fatty acid content of A40926 complex and that of the longer homologues in the producer mycelia. |
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