Reusable Co-nanoparticles for general and selective N-alkylation of amines and ammonia with alcohols |
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| Authors: | Zhuang Ma Bei Zhou Xinmin Li Ravishankar G Kadam Manoj B Gawande Martin Petr Radek Zbo&#x;il Matthias Beller Rajenahally V Jagadeesh |
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| Institution: | Leibniz-Institut für Katalyse e.V., Albert-Einstein-Str. 29a, Rostock D-18059 Germany.; Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University Olomouc, Šlechtitelů 27, 73 71, Olomouc Czech Republic ; Nanotechnology Centre, Centre of Energy and Environmental Technologies, VŠB–Technical University of Ostrava, 17. Listopadu 2172/15, Ostrava-Poruba 708 00 Czech Republic |
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| Abstract: | A general cobalt-catalyzed N-alkylation of amines with alcohols by borrowing hydrogen methodology to prepare different kinds of amines is reported. The optimal catalyst for this transformation is prepared by pyrolysis of a specific templated material, which is generated in situ by mixing cobalt salts, nitrogen ligands and colloidal silica, and subsequent removal of silica. Applying this novel Co-nanoparticle-based material, >100 primary, secondary, and tertiary amines including N-methylamines and selected drug molecules were conveniently prepared starting from inexpensive and easily accessible alcohols and amines or ammonia.A general cobalt-catalyzed N-alkylation of amines with alcohols by borrowing hydrogen methodology to prepare different kinds of amines is reported. |
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