Asymmetric synthesis of oxindoles containing a quaternary stereogenic centre by catalytic O/C-carboxyl rearrangement |
| |
| Authors: | Muhammad Ismail Gennadiy Ilyashenko Christopher J Richards |
| |
| Institution: | a School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, NR4 7TJ, UK
b School of Biological and Chemical Sciences, Queen Mary, University of London, E1 4NS, UK |
| |
| Abstract: | A catalysed O/C-carboxyl rearrangement generates the all-carbon stereogenic centre in phenyl 1,3-dimethyl-5-methoxy-2-oxoindoline-3-carboxylate (up to 57% ee). Crystallisation and removal of racemic crystals enhance the ee to 95%. The X-ray crystal structure of the cobalt metallocene-pyrrolidinopyridine nucleophilic catalyst employed is reported. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
