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Microwave-assisted synthesis of azetidines in aqueous media |
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| Authors: | Brendan A. Burkett Samuel Z. Ting Christina L.L. Chai |
| Affiliation: | a New Synthesis Techniques and Applications, Institute of Chemical and Engineering Sciences, A*STAR, 1 Pesek Road, Jurong Island, Singapore 627833, Singapore b School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand |
| Abstract: | Simple azetidines are synthesized in good to excellent yields and high purity via cyclization of 3-(ammonio)propyl sulfates derived from primary amines and the cyclic sulfate of 1,3-propanediol. A feature of this methodology includes the accelerated synthesis of azetidines in water under the influence of microwave-assisted heating. |
| Keywords: | Azetidines Microwaves Cyclization Cyclic sulfates Green chemistry |
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