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A facile one-step synthesis of 5-chloro-imidazo[1,5-a]quinazoline by microwave irradiation |
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| Authors: | Guo Li Ramesh Kakarla Annapurna Pendri |
| Affiliation: | a Early Discovery Chemistry, Bristol Myers Squibb R&D, 5 Research Parkway, Wallingford, CT 06492, USA b PTC Therapeutics Inc., 100 Corporate Ct, South Plainfield, NJ 07080, USA c Merial Limited, 631 Route 1, North Brunswick, NJ 08902, USA |
| Abstract: | A new and facile method has been developed for the one-step synthesis of 5-chloro-imidazo[1,5-a]quinazoline by cyclization of N-acylanthranilic acid A with 2-amino acetamide B1 or 2-amino-acetonitrile B2 in the presence of POCl3 under microwave irradiation. 5-chloro-imidazo[1,5-a]quinazolines can be further functionalized by displacement of 5-Cl group. |
| Keywords: | Imidazoquinazoline 4-Quinazolinone Microwave |
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