1H- and 13C-NMR Study of Some 6,7-Dihaloquinolone Nucleosides and Their Derivatives |
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| Authors: | Najim A Al-Masoudi Yaseen A Al-Soud Armin Geyer |
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| Institution: | 1. Faculty of Chemistry , University of Konstanz , D-78434 , Konstanz , Germany;2. Faculty of Science , Al-Isra University , Amman-Jordan |
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| Abstract: | The 1H- and 13C-NMR spectra of 6,7-dihalo-1,4-dihydro-4-oxo-1-(2,3,5-tri-0-benzoyl-pβ-D-ribofuranosyl)quinoline-3-carboxylic acids (3), (4), the ester (3a), 6-chloro-1-(2-deoxy-3,5-di-O-tolouyl-α- and β-D-erythropentofuranosyl)-7-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (5), and its free a-nucleoside (5a) have been investigated. Resonance signals were assigned by homo- and heteronuclear two dimensional NMR methods (DQF-COSY, HMQC, and HMBC) for (3), (4), (5), and (5a). Ribosylation sites and anomeric configurations were identified from ROESY spectra. |
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| Keywords: | quinolone nucleosides 1H- and 13C-NMR 2D-NMR (ROESY HMBC HMQC) |
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