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Ultraviolet Spectroscopic Study of Cu2+ Induced DNA Melting at Room Temperature |
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| Authors: | K K Deb |
| Institution: | 1. U.S. Army Night Vision &2. Electro-Optics Laboratory Laser Division |
| Abstract: | Complexes of Calf thymus DNA with Cu2+ ions have been studied using ultraviolet (UV) absorption spectroscopy to probe the binding and melting behavior of DNA in the complex at 25°C, causing a melting of DNA as effectively as heating to 100°C. This strengthens the concept of Cu2+ binding to the DNA bases as recently demonstrated by Richard et al.1 |
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