Transition Metal Induced Conformational Change of Heme Proteins |
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| Authors: | Pijush Basak Rudradip Pattanayak |
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| Affiliation: | Department of Biochemistry , University of Calcutta , Kolkata , India |
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| Abstract: | Binding interaction of transition metals copper, cadmium, and mercury with heme proteins were explored using isothermal calorimetry. Consequent conformational changes of the native proteins analyzed by circular dichroic spectroscopy revealed differential structural alteration of heme proteins. But, significant distortion in myoglobin structure was noted due to bioconjugation with mercury whose greater ionic radius may be responsible for this preferential behavior. |
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| Keywords: | conformational change heme protein isothermal calorimetry mean residual elipticity transition metal ions |
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