| 用于基因和药物传递的多肽及聚多肽材料 |
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| 引用本文： | 陈荆晓,王慧媛,许小丁,陈巍海,张先正.用于基因和药物传递的多肽及聚多肽材料[J].高分子学报,2011(8):799-811. |
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| 作者姓名： | 陈荆晓 王慧媛 许小丁 陈巍海 张先正 |
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| 作者单位： | 武汉大学化学与分子科学学院 生物医用高分子材料教育部重点实验室 武汉430072 |
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| 摘 要： | 多肽和聚多肽作为一类新型的生物医用材料,由于其具有良好的生物活性、生物可降解性以及生物相容性而备受瞩目.将具有特殊生理功能的多肽作为基因或药物载体、或用于药物修饰等,可以提高基因转染效率,增强药物的靶向治疗效果,降低药物的毒副作用.本文综述了近年来多肽及聚多肽材料在这些生物医学领域的应用及进展,对部分活性肽的作用机制和...
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| 关 键 词： | 多肽 聚多肽 基因载体 药物传递 癌症治疗 |
PEPTIDES AND POLYPEPTIDES FOR GENE AND DRUG DELIVERY |
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| CHEN Jingxiao,WANG Huiyuan,XU Xiaoding,CHEN Weihai,ZHANG Xianzheng.PEPTIDES AND POLYPEPTIDES FOR GENE AND DRUG DELIVERY[J].Acta Polymerica Sinica,2011(8):799-811. |
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| Authors: | CHEN Jingxiao WANG Huiyuan XU Xiaoding CHEN Weihai ZHANG Xianzheng |
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| Abstract: | Peptides and polypeptides have been widely used for gene and drug delivery due to their inherent bioactivity,biodegradability and well biocompatibility.Due to the specific bioactivity of peptides,peptide-based gene and drug delivery systems could achieve improved gene transfection efficiency,enhanced drug targeting property and reduced side-effect.This article reviews the recent progress in peptides and polypeptides as gene and drug carriers.The mechanism and characteristics of some bioactive peptides were also introduced.Finally,the prospect of bioactive peptides in cancer treatments was proposed. |
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| Keywords: | Peptide Polypeptide Gene vector Drug delivery Cancer therapy |
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