| 符合经典构效关系的抗肿瘤铂类药物 |
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| 引用本文： | 王联红,刘芸,苟少华,尤启冬.符合经典构效关系的抗肿瘤铂类药物[J].化学通报,2003,66(12):828-836. |
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| 作者姓名： | 王联红 刘芸 苟少华 尤启冬 |
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| 作者单位： | [1]南京大学配位化学国家重点实验室，南京210093 [2]中国药科大学药学院，南京210009 |
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| 摘 要： | 综述了自顺铂、卡铂后符合经典构效关系的铂类抗肿瘤药物的发展概况，按载体配基和离去基团的结构特征进行了分类，总结了各类配合物的构效关系和临床进展，其中重点对手性二胺配体的铂(Ⅱ)配合物进行了介绍。并讨论了顺铂、卡铂、奥沙利铂的作用机理。
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| 关 键 词： | 铂类抗肿瘤药物 经典构效关系 手性配体 顺铂 卡铂 奥沙利铂 作用机理 |
| 修稿时间： | 2002年12月6日 |
Antitumor Platinum Drugs in accord with Classical Structure-Activity Relationships |
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| Wang Lianhong ,Liu Yun,Gou Shaohua ,You Qidong.Antitumor Platinum Drugs in accord with Classical Structure-Activity Relationships[J].Chemistry,2003,66(12):828-836. |
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| Authors: | Wang Lianhong Liu Yun Gou Shaohua You Qidong |
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| Institution: | Wang Lianhong 1,2,Liu Yun1,Gou Shaohua 1*,You Qidong 2 |
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| Abstract: | This article reviews the progress in antitumor platinum drugs following cisplatin and carboplatin.These complexes are classified according to their structural characteristics of carrier ligands and leaving groups,whose structure -activity relationships and clinical trials are summarized.Antitumor platinum drugs with chiral diamines as ligands are emphasized.The mechanism of cisplatin,carboplatin and oxaliplatin are discussed. |
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| Keywords: | Antitumor platinum drugs Classical structure-activity relationships Chiral ligands |
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