A Preloaded Amorphous Calcium Carbonate/Doxorubicin@Silica Nanoreactor for pH‐Responsive Delivery of an Anticancer Drug |
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| Authors: | Dr Yang Zhao Dr Zhong Luo Menghuan Li Qiuyu Qu Xing Ma Prof Shu‐Hong Yu Prof Yanli Zhao |
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| Institution: | 1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore) http://www.ntu.edu.sg/home/zhaoyanli/;2. School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798 (Singapore);3. Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P.R. China) http://staff.ustc.edu.cn/～yulab/ |
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| Abstract: | Biomedical applications of nontoxic amorphous calcium carbonate (ACC) nanoparticles have mainly been restricted because of their aqueous instability. To improve their stability in physiological environments while retaining their pH‐responsiveness, a novel nanoreactor of ACC–doxorubicin (DOX)@silica was developed for drug delivery for use in cancer therapy. As a result of its rationally engineered structure, this nanoreactor maintains a low drug leakage in physiological and lysosomal/endosomal environments, and responds specifically to pH 6.5 to release the drug. This unique ACC–DOX@silica nanoreactor releases DOX precisely in the weakly acidic microenvironment of cancer cells and results in efficient cell death, thus showing its great potential as a desirable chemotherapeutic nanosystem for cancer therapy. |
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| Keywords: | amorphous calcium carbonate antitumor agents doxorubicin drug delivery medicinal chemistry |
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