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Diketopyrrolopyrrole‐Porphyrin Conjugates with High Two‐Photon Absorption and Singlet Oxygen Generation for Two‐Photon Photodynamic Therapy |
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| Authors: | Julie Schmitt Prof Valérie Heitz Dr Angélique Sour Dr Frédéric Bolze Dr Hussein Ftouni Prof Jean‐Francois Nicoud Dr Lucia Flamigni Dr Barbara Ventura |
| Institution: | 1. LSAMM, Institut de Chimie de Strasbourg, CNRS/UMR 7177, 4 rue Blaise Pascal, 67000 Strasbourg (France);2. CAMB, UMR 7199, UdS/CNRS, Faculté de Pharmacie, 74 route du Rhin, 67401 Illkirch (France);3. Istituto ISOF‐CNR, Via P. Gobetti 101, 40129 Bologna (Italy) |
| Abstract: | Two‐photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two‐photon absorption and singlet‐oxygen generation. Reported here are two new diketopyrrolopyrrole‐porphyrin conjugates as robust two‐photon absorbing dyes with high two‐photon absorption cross‐sections within the therapeutic window. Furthermore, for the first time the singlet‐oxygen generation efficiency of diketopyrrolopyrrole‐containing systems is investigated. A preliminary study on cell culture showed efficient two‐photon induced phototoxicity. |
| Keywords: | diketopyrroles dyes/pigments photodynamic therapy porphyrins singlet oxygen two‐photon absorption |