One-pot tandem decarboxylative allylation-Heck cyclization of allyl diphenylglycinate imines: rapid access to polyfunctionalized 1-aminoindanes |
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| Authors: | Fields Wendy H Khan Ali K Sabat Michal Chruma Jason J |
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| Affiliation: | Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319, USA. |
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| Abstract: | ![]()
1-Aminoindanes are generated from allyl diphenylglycinate imines employing a "one-pot" palladium-catalyzed decarboxylative allylation-Heck cyclization cascade. Variation of both the aryl and allyl moieties leads to a diverse range of polycyclic imines, amenable to the synthesis of natural products and other biologically relevant small molecules. |
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