A Versatile Total Synthesis of 8‐Oxyberberine and Oxohomoberberines |
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| Authors: | Yun He Yang Zheng Li Hai Yong Wu |
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| Affiliation: | Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China |
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| Abstract: | The total syntheses of 8‐oxyberberine and oxohomoberberines were accomplished starting from commercially available 5‐bromobenzo[d][1,3]dioxole, piperonal and sesamol in high total yield. The key steps involved a modified Pomeranz‐Fritsch reaction and the intramolecular Heck cyclization. This approach is short, convenient and suitable for the preparation of homoberberine analogues. |
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| Keywords: | synthetic method total synthesis oxohomoberberines modified Pomeranz‐Fritsch reaction intramolecular Heck cyclization |
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