| A Convenient Method for Synthesis of Novel Cyclic Ethers (1R,2R,3R,5S,7S,9R,12R)-3-(t-Butyldimethylsilyl)oxy-7-methoxymethyl-oxy-2,10-dimethyl-12-oxatricyclo [7.2.1.0~(5,12)] dodecane |
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| 作者姓名： | Jie YAN Min ZHU College of Pharmaceutical Sciences Zhejiang University of Technology Hangzhou College of Biological and Environmental Sciences Zhejiang Shuren University Hangzhou |
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| 作者单位： | Jie YAN1，Min ZHU2 1 College of Pharmaceutical Sciences，Zhejiang University of Technology，Hangzhou 310032 2College of Biological and Environmental Sciences，Zhejiang Shuren University，Hangzhou 310015 |
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| 摘 要： | Coloradocin, a novel macrolide antibiotic from cultures of Actinoplanes coloradoensis1exhibits activity against pathogenic anaerobic and microaerophilic species2. Because itslow toxicity and substantial oral activity3, , as well as its unusual structure5, several 4research groups initiated approaches towards the synthesis of coloradocin6, whichculminated in the synthesis of 18-deoxynargenicin A1 by Kallmerten et al.7. …
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A Convenient Method for Synthesis of Novel Cyclic Ethers (1R, 2R,3R, 5S, 7S, 9R, 12R)-3-(t-Butyldimethylsilyl)oxy-7-methoxymethyloxy-2, 10-dimethyl-12-oxatricyclo [7.2.1.05,12] dodecane |
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| Jie YAN,Min ZHU College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou College of Biological and Environmental Sciences,Zhejiang Shuren University,Hangzhou .A Convenient Method for Synthesis of Novel Cyclic Ethers (1R,2R,3R,5S,7S,9R,12R)-3-(t-Butyldimethylsilyl)oxy-7-methoxymethyl-oxy-2,10-dimethyl-12-oxatricyclo [7.2.1.0~(5,12)] dodecane[J].Chinese Chemical Letters,2005,16(4). |
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| Authors: | Jie YAN Min ZHU College of Pharmaceutical Sciences Zhejiang University of Technology Hangzhou College of Biological and Environmental Sciences Zhejiang Shuren University Hangzhou |
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| Institution: | Jie YAN1,Min ZHU2 1 College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou 310032 2College of Biological and Environmental Sciences,Zhejiang Shuren University,Hangzhou 310015 |
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| Abstract: | Novel cyclic esters (1R, 2R, 3R, 5S, 7S, 9R, 12R)-3-(t-butyldimethylsilyl)oxy-7- methoxymethyloxy-2, 10-dimethyl-12-oxatricyclo 7.2.1.05,12] dodecane were prepared when their precursor 1 was treated with SOCl2/pyridine. A plausible mechanism was hypothesized. |
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| Keywords: | R 2R 3R 5S 7S 9R 12R)-3-(t-Butyldimethylsilyl)oxy-7-methoxymethyloxy-2 10-dimethy-12-oxatricyclo [7 2 1 05 12] dodecane synthesis mechanism |
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