Enantioselective total synthesis of the potent anti-HIV nucleoside EFdA |
| |
| Authors: | Kageyama Masayuki Nagasawa Tomohiro Yoshida Mayumi Ohrui Hiroshi Kuwahara Shigefumi |
| |
| Affiliation: | Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori-Amamiyamachi, Sendai 981-8555, Japan. |
| |
| Abstract: | A concise enantioselective total synthesis of 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA), an extremely potent anti-HIV agent, has been accomplished from (R)-glyceraldehyde acetonide in 18% overall yield by a 12-step sequence involving a highly diastereoselective ethynylation of an α-alkoxy ketone intermediate. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
