Synthesis and Crystal Structure of N-cyclopropyl-9 -（3,4-dicholophenyl）- 1,2,3,4,5,6,7,8,9,10-decahydroacridine -1,8-dione under Microwave Irradiation

1 INTRODUCTION aryl or methyl group to the nitrogen atom of these compounds leads to enhanced activities of fluo- A lot of natural and synthetic compounds con- rescence[7, . Since the pyridine scaffold is included 8] taining acridine skeletons display interesting biolo- in decahydroacridine-1,8-dione, a question is whether gical and physical activities[1]. Acridinedione, for the same modification on the nitrogen atom of de- example, has been identified as antimalarial and cahydroacridine-1…

Synthesis and Crystal Structure of N-cyclopropyl-9-(3,4-dicholophenyl)-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione under Microwave Irradiation

The N-cyclopropyl-9-(3,4-dicholophenyl)-1,2,3,4,5,6,7,8,9,10-decahydroacri- dine-1,8-dione was synthesized by the reaction of 1,3-cyclohexanedione, N-cyclopropylamine and 3,4-dicholoaldehyde in water and glycol under microwave irradiation. Its crystal structure was determined by single-crystal X-ray diffraction analysis. It possesses P212121 space group, with a = 9.9103(5), b = 13.3597(8), c = 14.5633(8)(A), V = 1928.16(18)(A)3, Mr = 402.30, Z = 4, Dc = 1.386 g/cm3, λ = 0.7107(A), μ(MoKα) = 0.354 mm-1 and F (000) = 840. The structure was refined to R = 0.0280 and wR = 0.0757. In the structure, the pyridine ring adopts a boat conformation.