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Comparison of in vitro breast cancer visibility in analyser‐based computed tomography with histopathology,mammography, computed tomography and magnetic resonance imaging
Authors:Jani Keyriläinen  Manuel Fernández  Alberto Bravin  Marja‐Liisa Karjalainen‐Lindsberg  Marjut Leidenius  Karl von Smitten  Mikko Tenhunen  Aki Kangasmäki  Petri Sipilä  Christian Nemoz  Pekka Virkkunen  Pekka Suortti
Abstract:High‐resolution analyser‐based X‐ray imaging computed tomography (HR ABI‐CT) findings on in vitro human breast cancer are compared with histopathology, mammography, computed tomography (CT) and magnetic resonance imaging. The HR ABI‐CT images provided significantly better low‐contrast visibility compared with the standard radiological images. Fine cancer structures indistinguishable and superimposed in mammograms were seen, and could be matched with the histopathological results. The mean glandular dose was less than 1 mGy in mammography and 12–13 mGy in CT and ABI‐CT. The excellent visibility of in vitro breast cancer suggests that HR ABI‐CT may have a valuable role in the future as an adjunct or even alternative to current breast diagnostics, when radiation dose is further decreased, and compact synchrotron radiation sources become available.
Keywords:breast cancer  computed tomography  magnetic resonance imaging  mammography  phase‐contrast imaging  X‐ray diffraction  X‐ray optics
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