| 新型2-芳氨基嘧啶衍生物的合成 |
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| 引用本文： | 马大友,余聂芳.新型2-芳氨基嘧啶衍生物的合成[J].有机化学,2008,28(8):1448-1453. |
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| 作者姓名： | 马大友 余聂芳 |
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| 作者单位： | 中南大学药学院,长沙,410013 |
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| 基金项目： | 中南大学升华学者基金，国家自然科学基金，中国博士后科学基金 |
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| 摘 要： | 通过间羟基苯硼酸与2,4-二氯嘧啶的Suzuki反应及其后酚羟基的烷基化得到4-芳基-2-氯嘧啶衍生物. 然后, 采用Pd(PPh3)4/dppf催化剂, 在温和的条件下实现了4-芳基-2-氯嘧啶类化合物和芳香胺的偶联. 合成了3个结构新颖的2-芳氨基嘧啶类化合物. 中间体及产物的结构均经由IR, 1H NMR, 13C NMR, MS和元素分析表征而予以证实.
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| 关 键 词： | Pd(PPh3)4 dppf 2-芳氨基嘧啶 偶联反应 |
| 收稿时间： | 2007-9-17 |
| 修稿时间： | 2007-12-14 |
Synthesis of Novel 2-(Substituted anilino)pyrimidine Derivatives |
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| MA,Da-You,YU,Nie-Fang.Synthesis of Novel 2-(Substituted anilino)pyrimidine Derivatives[J].Chinese Journal of Organic Chemistry,2008,28(8):1448-1453. |
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| Authors: | MA Da-You YU Nie-Fang |
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| Institution: | School of Pharmacy, Central South University, Changsha 410013 |
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| Abstract: | 4-(m-Substituted phenyl)-2-choloro-pyrimidines were prepared by Suzuki coupling reaction of 3-hydroxyphenylboronic acid with 2,4-dichloropyrimidine followed by alkylation of the hydroxyl group, which were effectively aminated by arylamine under catalysis of Pd(PPh3)4/dppf. Three novel 2- 2-(substituted anilino)pyrimidine derivatives were thus conveniently synthesized. The structures of all the synthesized compounds were fully characterized by IR, 1H NMR, 13C NMR, mass spectra and elemental analysis. |
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| Keywords: | Pd(PPh3)4 dppf |
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