An efficient one-pot route to symmetrically and unsymmetrically substituted 1,4,7-triazacyclononanes also results in the isolation of a stable macrocyclic aminal |
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| Authors: | Sonia Pulacchini Michael Watkinson |
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| Institution: | aDepartment of Chemistry, Queen Mary and Westfield College, London E1 4NS, UK |
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| Abstract: | A one-pot methodology has been developed for the direct synthesis of symmetrically and unsymmetrically N-substituted derivatives of 1,4,7-triazacyclononane. In the course of these studies the unexpected eight-membered cyclic aminal 7 has been isolated via an acid-catalysed rearrangement of enamine 5. |
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| Keywords: | aminals aza compounds enamines macrocycles polyamides polyazacycloalkanes |
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