| 高分子复合药物(阿司匹林和烟酸)的合成与表征 |
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| 引用本文： | 孙玉,孙礼林,沈良骏. 高分子复合药物(阿司匹林和烟酸)的合成与表征[J]. 合成化学, 2003, 11(5): 373-375 |
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| 作者姓名： | 孙玉 孙礼林 沈良骏 |
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| 作者单位： | 安徽师范大学化学与材料科学学院,安徽,芜湖,241000;安徽师范大学化学与材料科学学院,安徽,芜湖,241000;安徽师范大学化学与材料科学学院,安徽,芜湖,241000 |
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| 基金项目： | 国家自然科学基金资助项目 (2 9773 0 0 1),安徽省教育厅科研基金资助项目(2 0 0 2KJ119) |
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| 摘 要： | 通过酰氯法分别由阿斯匹林和烟酸与甲基丙烯酸-2-羟基乙酯合成了含阿司匹林的可聚合单体(A)和含烟酸的可聚合单体(B),然后将它们进行了聚合,得到了含阿司匹林和烟酸的复合药物。测定了A和B的竞聚率,产物经核磁共振及凝胶渗透色谱表征。
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| 关 键 词： | 阿司匹林 烟酸 聚合 复合药物 |
| 文章编号： | 1005-1511(2003)05-0373-03 |
| 修稿时间： | 2003-05-30 |
Synthesis and Characterization of Complex Drugs(Aspirin and Nicotinic Acid) |
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| SUN Yu,SUN Li lin,SHENG Liang jun. Synthesis and Characterization of Complex Drugs(Aspirin and Nicotinic Acid)[J]. Chinese Journal of Synthetic Chemistry, 2003, 11(5): 373-375 |
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| Authors: | SUN Yu SUN Li lin SHENG Liang jun |
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| Abstract: | The monomer(A) containing aspirin and the monomer(B) containing nicotinic acid were synthesized using the method of acyl chloride. Then the complex drugs containing both aspirin and nicotinic acid were obtained by copolymerization of A and B. The reactivity ratios of A and B were also determined. All products were characterized with 1H NMR and GPC. |
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| Keywords: | aspirin nicotinic acid polymerize complex drugs |
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