| 基于天然氨基酸的双环手性季铵盐相转移催化剂的合成及催化性能研究 |
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| 引用本文： | 沈宗旋,孔爱娣,施梅,张雅文.基于天然氨基酸的双环手性季铵盐相转移催化剂的合成及催化性能研究[J].有机化学,2003,23(7):701-704. |
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| 作者姓名： | 沈宗旋 孔爱娣 施梅 张雅文 |
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| 作者单位： | 1. 苏州大学化学化工系,苏州,215006
2. 南京晓庄学院北圩校区,南京,210017 |
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| 基金项目： | 江苏省教育厅自然科学基金(No.01KJB150002) |
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| 摘 要： | 以L－脯氨酸及L－羟基脯氨酸为原料合成了4个新型手性季铵盐磁相转移催化 剂，并用于催化不对称查耳酮环氧化反应，高产率得到相应环氧化合物，ee最高达 9％。
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| 关 键 词： | 相转移催化 氨基酸 季铵 查耳酮 不对称合成 环氧化反应 脯氨酸 |
| 修稿时间： | 2002年10月21 |
Synthesis and Catalytic Activities of Bicyclic Chiral Ammonium Salt Phase-Transfer Catalysts Based on Natural Amino Acids |
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| SHEN,Zong-Xuan KONG,Ai-Di SHI,Mei ZHANG,Ya-Wen.Synthesis and Catalytic Activities of Bicyclic Chiral Ammonium Salt Phase-Transfer Catalysts Based on Natural Amino Acids[J].Chinese Journal of Organic Chemistry,2003,23(7):701-704. |
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| Authors: | SHEN Zong-Xuan KONG Ai-Di SHI Mei ZHANG Ya-Wen |
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| Institution: | Department of Chemistry & Chemical Engineering, Suzhou University;Nanjing Xiaozhuang Institute, Beiwei Campus |
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| Abstract: | Four chiral quaternary ammonium salts were designed and synthesized from naturally occurring L-proline and L-hydroxyproline. These compounds were employed as phase-transfer catalysts in asymmetric epoxidation reactions of chalcone affording the corresponding epoxide in high yeilds and up to 9% ee. |
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| Keywords: | chiral phase-transfer catalyst natural amino acid quaternary ammonium salt chalcone asymmetric epoxidation |
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