Modification of natural coumarins reaction of khellactone esters with amines

The reaction of diesters of khellactone with primary and secondary amines under mild conditions has given derivatives of 4-aminodihydroseselin. Under more severe conditions, not only the replacement of a 4-acyloxy group by an amino group but also the opening of the lactone ring with the formation of the corresponding cinnamamide takes place. The ease of hydrolysis of the 3-acyloxy group and subsequent esterification of the alcohols formed and also the use of various amines makes it possible to obtain very diverse acyloxy and amino derivatives.All-Union Scientific-Research Institute of Medicinal Plants, Moscow. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 488–499, July–August, 1980.