Artocarpol A,a Novel Constituent with Potent Anti‐inflammatory Effect,Isolated from Artocarpus rigida

A novel phenolic compound, artocarpol A ( 1 ), was isolated from the root bark of Artocarpus rigida and its structure determined by spectroscopic methods and by comparison with its diacetate derivative. Compound 1 strongly inhibited superoxide formation in phorbol 12‐myristate 13‐acetate (PMA) stimulated rat neutrophils in a concentration‐dependent manner with an IC₅₀ value of 13.7±0.7 μM . Compound 1 also showed a significant inhibitory effect on tumor necrosis factor‐α (TNF‐α) formation in lipopolysaccharide(LPS)‐stimulated RAW 264.7 cells.