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Metathesis cascade strategies (ROM-RCM-CM): a DOS approach to skeletally diverse sultams |
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| Authors: | Kyu Ok Jeon Dinesh Rayabarapu Alan Rolfe Kelly Volp Iman Omar Paul R. Hanson |
| Affiliation: | a Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USA b The Center for Chemical Methodologies and Library Development at the University of Kansas (KU-CMLD), 2121 Simons Drive, Structural Biology Center, West Campus, Lawrence, KS 66047, USA |
| Abstract: | The development of a ring-opening metathesis/ring-closing metathesis/cross-metathesis (ROM-RCM-CM) cascade strategy to the synthesis of a diverse collection of bi- and tricyclic sultams is reported. In this study, functionalized sultam scaffolds derived from intramolecular Diels-Alder (IMDA) reactions undergo metathesis cascades to yield a collection of tricyclic sultams. Additional appendage-based diversity was achieved by utilizing a variety of CM partners. |
| Keywords: | Cascade Sultam RCM DOS |
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