|
|||||
|
|
Aigialomycins and related polyketide metabolites from the mangrove fungus Aigialus parvus BCC 5311 |
|
| Authors: | Masahiko Isaka Arunrat Yangchum Kanokarn Kocharin Palangpon Kongsaeree Samran Prabpai |
| Institution: | a National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand b Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand c Center for Excellence in Protein Structure and Function, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand |
| Abstract: | Reinvestigation of the secondary metabolites from the marine mangrove fungus Aigialus parvus BCC 5311 led to the isolation of six new nonaketide metabolites, aigialomycins F (4) and G (5a/5b), 7′,8′-dihydroaigialospirol (7), 4′-deoxy-7′,8′-dihydroaigialospirol (8), and rearranged macrolides 9 and 10, along with six previously described compounds, hypothemycin (1), aigialomycins A (2) and B (3), aigialospirol (6), 4-O-demethylhypothemycin (11), and aigialone (12). The structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data in combination with chemical means. |
| Keywords: | Aigialus parvus Resorcylic acid lactone Marine fungi Aigialomycin Aigialospirol |
| 本文献已被 ScienceDirect 等数据库收录！ | |