Synthesis of biologically active amines via rhodium-bisphosphite-catalyzed hydroaminomethylation |
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| Authors: | Briggs John R Klosin Jerzy Whiteker Gregory T |
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| Institution: | Chemical Sciences, The Dow Chemical Company, Midland, Michigan 48674, USA. |
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| Abstract: | reaction: see text] We report the use of a highly regioselective rhodium-bisphosphite catalyst for olefin hydroaminomethylation. This catalyst system was successfully applied in the synthesis of two biologically active tertiary amines, ibutilide and aripiprazole. |
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