Large scale Biginelli reaction via water-based biphasic media: a green chemistry strategy |
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| Authors: | Ajay K Bose Maghar S Manhas Suhas Pednekar Subhendu N Ganguly Hoang Dang William He Arun Mandadi |
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| Institution: | George Barasch Bioorganic Research Laboratory, Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA |
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| Abstract: | An important stage in process development is kilo scale preparation of the target compound. For this reason, a procedure involving water-based biphasic reaction media has been developed for conducting some exothermic reactions on a large scale. This protocol is illustrated by the energy-efficient and rapid preparation of dihydropyrimidinones by a solvent-free, green chemistry procedure applied to the Biginelli reaction using p-toluenesulfonic acid as catalyst. |
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| Keywords: | Biginelli reaction Biphasic media Dihydropyrimidinones p-TSA as catalyst |
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