Cymodienol and cymodiene: new cytotoxic diarylheptanoids from the sea grass Cymodocea nodosa |
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Authors: | Ioanna Kontiza Jasmin Jakupovic Christos Roussakis |
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Institution: | a University of Athens, School of Pharmacy, Department of Pharmacognosy and Chemistry of Natural Products, Panepistimiopolis Zografou, Athens 157 71, Greece b AnalytiCon Discovery GmbH, Hermannswerder Haus 17, 14473 Potsdam, Germany c ISOMer, Laboratoire de Pharmacogénomique Marine, Faculté de Pharmacie, 1 Rue Gaston Veil, F-44035 Nantes, France |
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Abstract: | The two new diarylheptanoids, cymodienol (1), and cymodiene (2), obtained from specimens of the sea grass Cymodocea nodosa, collected from the coastal areas of central Greece, are the first members of this class isolated from marine organisms. The chemical structures of the two metabolites were assigned on the basis of their NMR and MS spectroscopic data, including information obtained by 1D- and 2D-NMR experiments. Metabolite 2 possesses an unprecedented skeleton that might be biosynthetically related to metabolite 1. Cymodienol (1) was found to exhibit significant cytotoxic activity against two lung cancer cell lines. |
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Keywords: | Cymodocea nodosa Diarylheptanoids Cymodienol Cymodiene |
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