Amberlyst-15-promoted efficient 2-halogenation of 1,3-keto-esters and cyclic ketones using N-halosuccinimides |
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| Authors: | H.M. Meshram P.N. Reddy K. Sadashiv J.S. Yadav |
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| Affiliation: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 007, India |
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| Abstract: | ![]()
A simple and rapid process has been developed for the α-monohalogenation of 1,3-keto-esters with N-halosuccinimides catalyzed by Amberlyst-15® at room temperature to produce the corresponding 2-halo 1,3-keto-esters in high yields. This protocol also extended to α-halogenation of cyclic ketones. |
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| Keywords: | Ion exchange resin N-Halosuccinimides Halogenation β-Keto-esters Cyclic ketones |
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