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Mevashuntin, a novel metabolite produced by inhibition of the mevalonate pathway in Streptomyces prunicolor |
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| Authors: | Kazuo Shin-ya Yukiko Umeda Kazuo Furihata Yoichi Hayakawa |
| Institution: | a Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan b Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan c Faculty of Pharmaceutical Sciences, Tokyo University of Science Noda, Chiba 278-8510, Japan d Tokyo University of Agriculture, Setagaya-ku, Tokyo 113-8657, Japan |
| Abstract: | Inhibition of the mevalonate pathway by an HMG-CoA reductase inhibitor, mevalotin, in Streptomyces prunicolor possessing both mevalonate and MEP pathways resulted in the production of a new metabolite mevashuntin that consisted of conjugated thiazolone and pyranonaphthoquinone moieties. |
| Keywords: | Mevalotin Naphthoquinone Thiazolone Mevalonate pathway Streptomyces prunicolor |
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