Highly reactive and enantioselective kinetic resolution of terminal epoxides with H2O and HCl catalyzed by new chiral (salen)Co complex linked with Al |
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| Authors: | Santosh Singh Thakur Seong-Jin Kim |
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| Institution: | a Department of Chemical Engineering, Inha University, Incheon 402751, South Korea
b RStech Corp. #305 Venture Town, 1688-5, Sinil-dong, Daedeok-gu, Daejeon 306-230, South Korea |
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| Abstract: | The asymmetric hydrolytic kinetic resolution (HKR) of racemic terminal epoxides by new easily synthesized dimeric chiral (salen)Co bearing Al, provides a practical and straightforward method for the synthesis of enantiomerically enriched terminal epoxides (>99% ee) and diols. An inorganic acid, HCl is applied first time for the asymmetric ring opening reaction of terminal epoxides. Reactions are conveniently carried out at room temperature under an air atmosphere. |
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| Keywords: | Chiral cobalt salen catalyst Terminal epoxides Asymmetric ring opening reactions Kinetic resolution |
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