New synthetic method of 1,2-diaryl-1,2-dicarba-closo-dodecaboranes employing aromatic nucleophilic substitution (SNAr) reaction |
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| Authors: | Kiminori Ohta |
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| Institution: | Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai 981-8558, Japan |
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| Abstract: | Aromatic nucleophilic substitution (SNAr) reaction of 1-phenyl-o-carborane with 4-nitrofluorobenzene in the presence of NaH or KOtBu proceeded smoothly to give 1-(4-nitrophenyl)-2-phenyl-o-carborane; similar reaction affords various 1,2-diaryl-o-carboranes, which are useful precursors for macromolecular construction and drug design. |
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| Keywords: | Carboranes Aromatic nucleophilic substitution reaction (SNAr) |
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