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An anti-herpes simplex virus-type 1 agent from Xylaria mellisii (BCC 1005) |
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| Authors: | Pattama Pittayakhajonwut Rapheephat Suvannakad Samran Prabpai Morakot Tanticharoen |
| Institution: | a National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113, Paholyothin Rd., Klong 1, Klong Luang, Pathum Thani 12120, Thailand b Royal Forest Department, Bangkok 10900, Thailand c Department of Chemistry and Center for Protein Structure and Function, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand |
| Abstract: | A structurally unique polyketide, mellisol (1) and 1,8-dihydroxynaphthol 1-O-α-glucopyranoside (3), were isolated from the fungus Xylaria mellisii (BCC 1005). The relative stereostructure of 1 was determined on the basis of X-ray crystallographic data. Compounds 1 and 3 exhibited activity against herpes simplex virus-type 1 with IC50 values of 10.50 and 8.40 μg/mL, respectively. They also showed cytotoxic activity against vero cells at the concentration of 40-50 μg/mL. |
| Keywords: | Xylaria mellisii Anti-HSV-1 Mellisol 1 8-Dihydroxynaphthol 1-O-α-glucopyranoside |
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