Synthesis and DNA binding properties of pyrrole amino acid-containing peptides |
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| Authors: | Tushar Kanti Chakraborty Bajjuri Krishna Mohan Souvik Maiti |
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| Institution: | a Indian Institute of Chemical Technology, Hyderabad 500 007, India
b Institute of Genomics and Integrative Biology, Mall Road, New Delhi 110 007, India |
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| Abstract: | Dimers of the pyrrole amino acid (Paa), 5-(aminomethyl)pyrrole-2-carboxylic acid, and its derivatives having Lys anchored on N- and C-termini bind in the minor groove of DNA with considerable apparent binding affinities. When the Lys unit is attached to the C-terminus, the resulting ligand binds to ds-DNA with twice the affinity, of the order of 105, than the one carrying two positive charges at the same end. |
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| Keywords: | Pyrrole amino acid DNA binding Minor groove Distamycin analogues |
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