Direct glycosylation: synthesis of alpha-indoline ribonucleosides |
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| Authors: | Chandra Tilak Brown Kenneth L |
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| Affiliation: | Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701-3132, United States |
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| Abstract: | A selective synthesis of α-anomers of indoline nucleosides is described. Ribonucleosides of indoline, dimethylindoline and 5-bromoindoline are readily prepared in good yield by reacting indoline bases directly with the protected sugar, 2,3-O-(1-methylethylidene) 5-O-(triphenylmethyl)-D-ribofuranose in dry ethanol or methylene chloride in presence of molecular sieves at 40-60 °C. |
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