A ring-closing metathesis route to 7-membered aza-heteroannulated sugars |
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| Authors: | Dominic M Laventine Paul M Cullis |
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| Institution: | Department of Chemistry, University of Leicester, Leicester LE1 7RH, UK |
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| Abstract: | Azepane rings have been constructed diastereoselectively upon a carbohydrate derivative utilising reductive amination and RCM. The stereochemistry of the ring junctions was confirmed by X-ray crystallography and NMR. Diastereoselective dihydroxylation has also been employed to afford a tetrahydroxylated azepane carbohydrate derivative with potential biological activity. |
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| Keywords: | Pyrrolidines Carbohydrate annulation Amino sugars Ring-closing metathesis |
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